Preimplantation Genetic Testing (PGT) at IVF Florida
Preimplantation genetic testing (PGT) is an advanced screening tool used during in vitro fertilization (IVF) to analyze embryos for chromosomal or genetic abnormalities before transfer. PGT can offer important insights for patients seeking to grow their families with fewer risks and more information.
When used appropriately and when clinically indicated, PGT can reduce the likelihood of miscarriage and increase the chance of a successful pregnancy by identifying embryos that are most likely to result in a healthy live birth.
How does PGT work?
PGT is the process of analyzing the genetic material in embryos created through IVF. This type of genetic testing allows embryologists to determine which embryos are chromosomally normal (a.k.a. “euploid”), and which embryos may carry abnormalities that could lead to failed implantation, miscarriage, or certain genetic conditions.
PGT does not change or alter the embryos. It simply provides more information about each one to help guide informed decisions.
IVF timeline with PGT
PGT is integrated into the IVF process.
Here’s what the typical IVF timeline with PGT looks like:
Step 1
Fertilization
Step 2
Embryo development
Step 3
PGT biopsy
Step 4
Freezing
Step 5
Testing
Step 6
Transfer
Step 1
Fertilization
Eggs and sperm are combined to create embryos.
Step 2
Embryo development
Embryos are grown to the blastocyst stage (day 5–7).
Step 3
PGT biopsy
A few cells are carefully removed from each embryo in a procedure called a PGT biopsy.
Step 4
Freezing
Embryos are cryopreserved (frozen) while awaiting test results.
Step 5
Testing
The biopsied cells are analyzed at a genetics lab.
Step 6
Transfer
Once results are in, your physician selects an embryo for transfer based on both quality and genetic findings.
Some patients may also choose to freeze embryos for future use or undergo preimplantation genetic testing (PGT) to screen embryos for genetic conditions.
Our expert care ensures every step of your IVF journey is personalized and informed.
Types of PGT
There are three main types of preimplantation genetic testing available at IVF Florida:
PGT-A (preimplantation genetic testing for aneuploidy)
Screens for abnormal numbers of chromosomes, which can lead to implantation failure, miscarriage, or conditions such as Down syndrome. This is the most common type of PGT test performed.
PGT-M (for monogenic disorders)
Used for patients known to carry specific inherited conditions (e.g., cystic fibrosis, Sickle Cell Disease or Tay-Sachs disease).
PGT-SR (for structural rearrangements)
Screens for translocations or other chromosomal rearrangements that may affect embryo development or viability.
Who should consider PGT?
PGT may be recommended for individuals or couples with certain risk factors, including:
PGT can also be used by patients using donor eggs, donor sperm, or embryos, depending on their medical and family history.
Additionally, in the absence of an indication listed above, many couples elect for PGT-A to allow for embryo gender selection and family balancing.
**While PGT does increase success for certain patients with certain medical histories as stated above, PGT is not always universally recommended for all patients in every IVF cycle. Your fertility physician will review the preimplantation genetic testing pros and cons with you and take into consideration all indications as part of building your customized treatment plan.**
Success rates for PGT and IVF
PGT has been shown to improve pregnancy rates in certain patient populations per embryo transfer by helping identify the embryos with the highest potential for implantation and live birth. It also significantly lowers the risk of miscarriage for many patients, especially those with age-related or chromosomal risk factors.
Success rates vary depending on maternal age, embryo quality, and the underlying diagnosis. At IVF Florida, our physicians work closely with each patient to determine whether PGT may enhance their chances of success.
Schedule a consultation to discuss IVF PGT and IVF
If you’re considering IVF and want to explore whether preimplantation genetic testing could benefit your treatment plan, our IVF Florida team is here to guide you. Schedule a consultation with a fertility specialist today to get started.